The science behind Daily Biofen

The classic synthetic NSAIDs are efficient, but also have important gastrointestinal, cardiovascular and nephrological side effects. In recent years, science has focused on researching anti-inflammatory substances that occur freely in nature, and which have long been suspected by mankind to have anti-inflammatory effects. Until recently, however, the mechanism of action was not or hardly known, and there was also no clarity about the best extraction methods to obtain sufficient purity and optimal dosage. For a number of substances, the current knowledge about this is far evolved and clear.

Daily Biofen is therefore registered as the first bio-NSAID, a European quality label for food supplements.

What is the mechanism of action?

The NF-kB molecule regulates the inflammatory immune response by controlling the transcription of DNA to produce inflammatory cytokines. Research has now shown that blocking the NF-kB pathway and other inflammatory mediators are the main mechanisms of action of natural anti-inflammatory products (Maroon et al, 2010). curcumin and boswellia are known to counteract inflammation by decreasing expression of NF-kB, as well as suppressing several activators of NF-kB  (Bannuru , 2018). It is only more recently that the mechanism of action of boswellia has been better identified, showing that it is mainly the acetylketone and ketone acids (AKBA and BKA) of the resin that are responsible for its anti-inflammatory effects.

Another important component of the inflammatory pathway is arachidonic acid. This is released by damaged cellular membranes and transformed into inflammatory mediators by, among other things, the enzymatic action of cyclooxygenase (COX) and lipooxygenase (LOX). Curcumin has an inhibitory effect on the expression of both COX (Goel et al, 2001; Plummer et al, 1999; Ramsewak et al., 2000; Zhang et al., 1999) as LOX (Ammon et al., 1993; Began et al. 1998; Skrzypczak-Jankun et al, 2000). It has also been shown that the release of arachidonic acid is prevented by the inhibitory effect of curcumin on phospholipase (Rao et al, 1995; Yamamoto et al, 1997).

Curcumin also directly suppresses the action of several inflammatory cytokines such as TNF-alpha and interleukin-1a and interleukin-8 (Xu et al, 1997-1998; Chan et al, 1995). curcumin also has an important anti-oxidative effect. Both curcumin and boswellia prevent the production and activation of matrix metalloproteinases (MMPs) that are thought to be partly responsible for chondrodegeneration in joints (Bannuru, 2018).

Bromelain  prevents the expression of both NF-kB and COX and also has a regulatory effect on PGE2 (Brien et al, 2004). Bromelain  acts as a proteolyic enzyme (protease) acting anti-inflammatory via the ERK pathway and suppressing killer T-cell activation. In addition, Bromelain  has a direct effect on specific pain mediators such as bradykinin.

Because of its proteolytic and fibrinolytic effect, Bromelain is also excellent for acute trauma with bruising, bruising and swelling (Pavan et al, 2012; Brien et al, 2004).

At which dosage does an effect occur?

Curcumin  The efficiency and optimal dosage of curcumin is mainly determined by the degree of uptake or bioavailability, which is dependent on of the purity and water solubility of the extract. For basal curcumin , a dose of 900mg/d is therefore recommended.

Boswellia   The concentration of acetyl ketone and ketone acids (AKBA and BKA) is important for efficacy, with a ratio of 30-40% at a dose of 450- 900 mg/d has been shown to be ideal.

Bromelain  Bromelain is easily absorbed by the body without losing its mode of action and efficiency. Recent scientific research already shows an effect from 200 mg/d with increasing efficiency up to a dose of 2000 mg/d. In general, a dose of 1000mg/d is therefore used as the average standard.

A recent meta-analysis and systematic review shows that both boswellia and curcumin provide statistically significant improvement in pain and function compared to placebo in knee osteoarthritis. Randomized controlled trials were also described that showed no significant difference in the comparison between curcumin and an NSAID (Bannuru et al, 2018). A second recent meta-analysis and systematic review confirms a clinically important and significant pain reduction with the use of curcumin and boswellia for patients with osteoarthritis (Liu et al, 2017). In addition, research has shown an additive anti-inflammatory effect when boswellia is taken together with curcumin (Maroon et al, 2010).

In osteoarthritis, several randomized double-blind studies show a similar anti-inflammatory effect with bromelain  as with classical treatment with synthetic NSAIDs (Singer et al, 1996; Klein et al, 2000;Singer et al, 2001;Tilwe et al, 2001; Kasemsuk et al, 2016).

Want more information about the science behind our ingredients? Download our extensive literature study below.

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The classic synthetic NSAIDs are efficient, but also have  important gastrointestinal, cardiovascular and nephrological side effects. In recent years, science has therefore focused on research into anti-inflammatory substances that occur freely in nature.
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